Mitrephorines A-E and Other Cytotoxic Aporphinoids from the Bark of <i>Mitrephora tomentosa</i>.

ABSTRACT: Six previously undescribed alkaloids, including three dimeric aporphine alkaloids, mitrephorines A-C (1-3), two aristolactam-aporphine alkaloids, mitrephorines D and E (4 and 5), and one 4,5-dioxoaporphine alkaloid, 8-methoxycepharadione A (6), accompanied by 13 previously identified compounds, were isolated from the bark of Mitrephora tomentosa. Their structures were determined by the analysis of UV, IR, NMR, and HRMS, while absolute configurations were assigned by chiral HPLC, specific rotation values, and ECD spectral data. Known compounds (7-19) were identified by comparison with literature data. The structure of mitrephorine A was verified by the analysis of single-crystal X-ray diffraction. Alkaloid dimers were isolated as mixtu

SUBMITTER: Sangsopha W 

PROVIDER: S-EPMC12481564 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature