Regioselective Synthesis of Alcohols by Catalytic Transfer Hydrogenation of Epoxides.

ABSTRACT: Reductive ring opening of readily available epoxides provides easy access to synthetically important alcohols. However, controlling the regioselectivity of the reaction under user-friendly conditions remains challenging. Here, we present an efficient methodology for regioselective transfer hydrogenation (TH) of epoxides to synthesize Markovnikov and anti-Markovnikov alcohols using 2-propanol as the hydrogen source. An [IrCl(cod)(NHC)] (cod = 1,5-cyclooctadiene, NHC = N-heterocyclic carbene) complex as a precatalyst enables the formation of secondary and tertiary alcohols in good to excellent yields via selective TH of mono- and 2,2-disubstituted terminal epoxides. Remarkably, we found that an NHC-Ir & Pd/C cooperative catalysis approach can steer the regioselectivity of the reaction to aff

SUBMITTER: Genc S 

PROVIDER: S-EPMC12481575 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature