Low-Density Lipoprotein Cholesterol Time in Target Range and Clinical Outcomes in the General Population.

ABSTRACT:

Background

Low-density lipoprotein cholesterol (LDL-C) is a well-established cardiovascular risk predictor. However, it remains unclear whether the changes in LDL-C over time characterized by time in target range (TTR) are associated with adverse clinical outcomes.

Objectives

This study aimed to investigate the association between LDL-C TTR and adverse outcomes in the general population.

Methods

In 8,813 ARIC (Atherosclerosis Risk In Communities) study participants with ≥2 LDL-C measures between the first (1987-1989) and fifth (2011-2013) visits, LDL-C TTR was defined as <70 mg/dL or <130 mg/dL for participants with or without prevalent atherosclerotic cardiovascular disease (CVD). Multivariable Cox models, competitive risk analysis, and a 10-year landmark analysis we

SUBMITTER: Huang J 

PROVIDER: S-EPMC12481614 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature