Development of carboximidamide small molecule nanogels as potent antimicrobial functional drug delivery systems.

ABSTRACT: The escalating threat of multidrug-resistant (MDR) bacterial infections necessitates innovative antimicrobial strategies with enhanced potency, selectivity, and pharmacokinetic profiles. In this study, chitosan/polyvinyl pyrrolidone (Cs/PVP) nanogels were developed to encapsulate hydrophobic scaffolds (phenyltriazole, phenylthiazole, and phenylguanidine derivatives) to improve solubility, stability, and antimicrobial efficacy. The nanogels exhibited nanoscale dimensions (35-320 nm), uniform spherical morphology, and good colloidal stability. Antimicrobial evaluation revealed significant fold potentiation of activity, with minimal inhibitory concentration (MIC) values reduced up to 64-fold against Gram-positive bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA)

SUBMITTER: Almohaywi B 

PROVIDER: S-EPMC12481680 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature