Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population.

ABSTRACT:

Background

House dust mites (HDM) are a major trigger factor of allergic diseases worldwide.

Objective

To characterize the group 22 allergen from the HDM Dermatophagoides pteronyssinus among Malaysian atopic adults.

Methods

Recombinant Der p 22 and 33 alanine mutants were expressed in Escherichia coli and purified. Specific IgE levels to group 22 allergens were measured in serum samples from a combined cohort of Malaysian adults (n = 176) and participants from the SMCGES sub-cohort (n = 755), with responses classified by ImmunoCAP classes. Age- and gender-adjusted multivariate logistic regression was used to assess associations between Class 3+ group 22-specific IgE responses (>3.5 IU/mL) and clinical diagnoses of asthma, allergic rhinitis (AR), and atop

SUBMITTER: Reginald K 

PROVIDER: S-EPMC12481711 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature