Cross-sectional analyses between the dietary index for gut microbiota and Parkinson's disease in the middle-aged and elderly population.

ABSTRACT:

Background

The evidence linking dietary indices to Parkinson's disease (PD) risk remains limited. This study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and PD risk in middle-aged and elderly populations.

Methods

Cross-sectional data were obtained from the 2007-2020 cycles of the National Health and Nutrition Examination Survey (NHANES), including 17,373 participants aged 40 years or older. PD was defined by antiparkinsonian medication use. DI-GM scores were calculated based on 14 dietary components. Multiple logistic regression and a restricted cubic spline model (RCS) were used to test the relationship between DI-GM and PD. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the results.

Results

Among

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC12481752 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature