Cumulative intra-abdominal pressure exposure and dynamic trajectories in ICU-admitted patients reveal prognostic determinants of severe acute pancreatitis.

ABSTRACT:

Background

Intra-abdominal pressure (IAP) critically drives organ failure progression in severe acute pancreatitis (SAP). However, traditional static IAP monitoring inadequately captures dynamic injury evolution. This study aimed to assess the impact of cumulative IAP exposure (CumIAP) and dynamic trajectories on the prognosis of SAP.

Methods

This retrospective cohort study analyzed 1,008 ICU-admitted SAP patients from the Jiangxi cohort (2005-2023) and 83 from MIMIC-IV (2008-2019). CumIAP was quantified via time-weighted integration of serial IAP measurements. Multivariate Cox regression models and restricted cubic splines (RCS) were established to analyze the dose-response relationships between CumIAP and death, infectious pancreatic necrosis (IPN), and persistent multiple

SUBMITTER: Kuang M 

PROVIDER: S-EPMC12481794 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature