Interaction between toll-like receptor 4 polymorphism and abdominal obesity on ovarian cancer risk in Chinese women.

ABSTRACT:

Objectives

the aim of this study was to evaluate the impact of TLR4 gene single nucleotide polymorphisms (SNPs) and additional TLR4 gene SNP- SNP and SNP- abdominal obesity (AO) interaction on ovarian cancer (OC) risk.

Methods

Generalized multifactor dimensionality reduction method were utilized to identify the most informative interactions between four SNPs in the TLR4 gene and abdominal obesity. Logistic regression was employed to investigate the association between 4 SNPs within TLR4 gene and OC risk, and additional SNP- SNP and gene- AO interaction on OC risk, ORs (95%CI) were calculated.

Results

The analysis of logistic regression indicated a markedly elevated risk of OC in individuals carrying either the rs4986790-G or rs11536889-C alleles in the TLR4 gene compa

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12481797 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature