Comparison of two transpulmonary pressure-based positive end-expiratory pressure titration strategies in acute respiratory distress syndrome: a randomized crossover study.

ABSTRACT:

Background

Esophageal pressure monitoring, which enables the estimation of transpulmonary pressure, has been proposed to personalize ventilator settings, particularly positive end-expiratory pressure (PEEP), in patients with acute respiratory distress syndrome (ARDS). Two conceptually different transpulmonary pressure-based PEEP titration strategies have thus been described but have never been compared. This study aims to compare the PEEP levels obtained with these two distinct strategies and their physiological effects.

Methods

This was a randomized crossover physiological study. Twenty patients with moderate to severe ARDS (PaO₂/FiO₂ < 150 mmHg) were included in an academic intensive care unit. The two transpulmonary pressure-based PEEP titration stra

SUBMITTER: Chean D 

PROVIDER: S-EPMC12481819 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature