Serum Vitamin D Levels Were Not Associated With the Risk of Aneurysmal Subarachnoid Hemorrhage: A Large Cohort Study With Propensity Score Matching and Mendelian Randomization Analysis.

ABSTRACT:

Background

Vitamin D (VitD) may protect arterial health, but its link to cerebral aneurysm rupture remains unclear. This study aims to investigate the correlation between serum VitD levels and the risk of aneurysmal subarachnoid hemorrhage (aSAH).

Methods

This retrospective study included patients with ruptured or unruptured aneurysms treated between 2018 and 2021. Univariate and multivariate analyses were conducted. Propensity score matching (PSM) analysis was conducted to balance confounding factors. Furthermore, the causal relationship between VitD and aSAH was investigated using a two-sample Mendelian randomization (MR) analysis. Summary-level data for the exposure (VitD) and outcome (aSAH) were obtained from public genome-wide association study datasets. Multiple MR met

SUBMITTER: Qiu H 

PROVIDER: S-EPMC12481830 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature