HMGB1-mediated macrophage polarization to M2 phenotype promotes ureteral stricture: therapeutic potential of HMGB1 inhibitors.

ABSTRACT:

Background

Ureteral stricture is a common condition characterized by fibrotic narrowing of the ureter, often resulting in obstruction and impaired renal function. The condition is typically associated with chronic inflammation, epithelial injury, and abnormal wound healing responses, leading to excessive deposition of extracellular matrix proteins. High Mobility Group Box 1 (HMGB1), a damage-associated molecular pattern (DAMP) protein, plays a key role in promoting inflammation and fibrosis in various tissues. However, its specific role in the pathogenesis of ureteral stricture remains unclear. Glycyrrhizin, a natural HMGB1 inhibitor, has shown therapeutic potential in alleviating inflammation and fibrosis in preclinical studies of other fibrotic diseases. This study explores the i

SUBMITTER: Zheng J 

PROVIDER: S-EPMC12481876 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature