Topical frankincense treatment on relieving high-risk diabetic foot in rats by reducing inflammation and improving microcirculation.

ABSTRACT:

Background

Frankincense, an ancient aromatic substance known for promoting blood circulation, is widely used in traditional Chinese medicine to treat skin lesions.

Methods

This study aimed to evaluate the efficacy and underlying mechanisms of frankincense oil extract (FOE) in addressing high-risk diabetic foot by improving microvascular circulatory disorders. The vascular repair effects of FOE were assessed in a streptozotocin-induced high-risk diabetic foot animal model. Various evaluations were performed, including infrared thermometry, motor nerve conduction velocity (MNCV) testing, laser Doppler flowmetry (LDF), hematoxylin and eosin (H&E) staining, and immunohistochemical analyses for CD31, TRPV3, β-catenin, MMP-9, and COX-2 expressions.

Results

The results showe

SUBMITTER: Ma SY 

PROVIDER: S-EPMC12481894 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature