Corneal Cross-Linking Induces Increased Corneal Refractive Index, Which Generates Measurement Error of Central Corneal Thickness.

ABSTRACT:

Purpose

This study investigated the impact of a higher-than-expected corneal index of refraction (n_c) on measured central corneal thickness (CCT) by Scheimpflug tomography and anterior-segment OCT.

Design

Theoretical analysis with prospective cohort study validation.

Participants

Twenty-four eyes from 23 participants met the criteria for inclusion in data analysis.

Methods

Two models were developed to represent side-view imaging with Scheimpflug geometry (model 1) and interferometric imaging in OCT (model 2). For both models, predicted CCT was calculated for various n_c values, and CCT measurement error was quantified. For validation, CCT was measured using Scheimpflug tomography and OCT in prospectively recruited subjects with keratoconus

SUBMITTER: Roberts CJ 

PROVIDER: S-EPMC12481905 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature