Plasma-reinforced dual-crosslinked Pueraria hydrogel coating for synergistic atherosclerosis intervention.

ABSTRACT: To address the clinical challenges of stent thrombosis and restenosis in atherosclerosis intervention, this study developed a dual-crosslinked hydrogel coating (PSMASH-integrating methacrylated Pueraria polysaccharide (PSMA) and thiolated derivative (PSSH) based on Pueraria lobata polysaccharide). We used an ion-assisted plasma polymerization (IAPP) technique to construct micro-nano structures and thiol-ene click reaction sites on the surface of 316L stainless steel stents. This approach enabled robust covalent integration between the coating and the substrate. Simultaneously, the dual-network architecture of the hydrogel coating (synergistic covalent and dynamic crosslinking) conferred enhanced mechanical stability and controlled degradation properties. PSMASH promoted endothelial cell re

SUBMITTER: Wang J 

PROVIDER: S-EPMC12481940 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature