Preoperative HBsAg seroclearance affects long-term outcomes for hepatitis B virus-related hepatocellular carcinoma after liver resection: a multicenter analysis.

ABSTRACT:

Background & aims

We aimed to investigate the impact of HBsAg seroclearance on the long-term prognosis of HBV-related HCC following curative liver resection.

Methods

Patients treated with curative-intent hepatectomy for HBV-related HCC in 4 Chinese hospitals were enrolled. Patients were stratified into HBsAg-positive and HBsAg-seroclearance groups. Overall survival (OS) and time-to-recurrence (TTR) were compared between HBsAg-positive and HBsAg-seroclearance patients using propensity score matching (PSM). Independent risk factors of OS, cancer-specific survival (CCS) and TTR were identified by univariable and multivariable Cox regression and competing risk regression analyses.

Results

Among 1008 HBV-related HCC patients, 81 (8.0%) patients achieved HBsAg seroclearance

SUBMITTER: Liu SY 

PROVIDER: S-EPMC12481949 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature