Effects of dietary L-glutamate and L-aspartate supplementation on growth performance, severity of diarrhea, intestinal barrier integrity, and fecal microbiota of weaned piglets challenged with F18 enterotoxigenic Escherichia coli.

ABSTRACT:

Background

L-Glutamate and L-aspartate are functional amino acids that play pivotal roles in the cellular metabolic pathways of swine enterocytes. Therefore, this study aimed to investigate the effects of dietary L-glutamate and L-aspartate on growth performance, diarrhea severity, intestinal barrier integrity, and fecal microbiota of weaned piglets challenged with F18 enterotoxigenic Escherichia coli (ETEC). Weaned piglets were randomly assigned to seven dietary treatments, including unchallenged and ETEC-challenged controls, amino acid-supplemented groups, and an antibiotic control, to assess their responses to ETEC challenge.

Results

Supplementation with 1% L-glutamate or 2% L-aspartate enhanced growth performance, with significantly greater (P < 0.05) average daily weigh

SUBMITTER: Wongchanla S 

PROVIDER: S-EPMC12482100 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature