Disentangling phonology from phonological short-term memory in Alzheimer's disease phenotypes.

ABSTRACT:

Background

Impaired phonological short-term memory is a core feature of the logopenic variant of primary progressive aphasia (lvPPA), but it is not clear whether a core phonological processing deficit is also present.

Methods

We asked three questions: (i) beyond short-term memory impairment, do lvPPA patients have an impairment within phonology itself?; (ii) is their performance in working memory and naming reflective of this phonological impairment?; and (iii) is their repetition performance related to structural and functional differences in key language-dominant regions? We compared non-word and word repetition and short-term memory performance in patients with typical Alzheimer's disease (tAD), lvPPA per consensus criteria, and others who previously satisfied definitions

SUBMITTER: Henderson SK 

PROVIDER: S-EPMC12482198 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature