Tailoring treatment for esophageal cancer: a retrospective comparison of chemoradiation with and without esophagectomy.

ABSTRACT:

Background

Locally advanced esophageal cancer remains a significant therapeutic challenge, with the optimal treatment strategy still debate. While previous studies suggest that concurrent chemoradiation therapy (CCRT) can improve survival, the role of esophagectomy following CCRT in patients with partial or no response has not been well-characterized, particularly in resource-limited settings. This study aimed to evaluate the survival benefit of esophagectomy following CCRT, with particular focus on non-complete responders (non-CR).

Methods

We conducted a retrospective cohort study of 132 patients with locally advanced esophageal cancer treated at Maharaj Nakorn Chiang Mai Hospital between 2013 and 2022. Patients were categorized based on initial treatment into preoperative

SUBMITTER: Toapichattrakul P 

PROVIDER: S-EPMC12482222 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature