Influence of C3'- and C4'-substitutions on fluorescence, crystal packing, and physicochemical properties of flavonol.

ABSTRACT: Natural flavonols exhibit a wide range of pharmacological activities and possess unique dual ESIPT (Excited-State Intramolecular Proton Transfer) fluorescence, making them sensitive to microenvironments. This sensitivity allows for the detection of metal ions, anions, small ligands, and biomacromolecules. However, the diversity in their structure, including the number and position of hydroxyl groups and potential chemical modifications, complicates the relationship between structure and fluorescence, posing challenges for their practical use as fluorescent probes. In this study, we focus on fine-tuning the ESIPT fluorescence, crystal packing, physicochemical properties, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) characteristics of a series of flavonols. We ac

SUBMITTER: Demidov OO 

PROVIDER: S-EPMC12482225 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature