Association between triglyceride-glucose index trajectories and in-hospital mortality in sepsis: a cohort study based on the MIMIC-IV database.

ABSTRACT:

Background

Sepsis remains a major challenge in critical care medicine, characterized by high incidence and mortality rates that severely threaten patient prognosis. Insulin resistance (IR) plays a pivotal role in the metabolic disturbances and adverse outcomes associated with sepsis. The triglyceride-glucose (TyG) index, as a readily attainable surrogate diagnostic for IR, has been frequently employed in clinical studies. The relationship between the TyG index's dynamic trajectories and clinical outcomes is yet unknown, though, as prior research has mostly assessed the index at a single time point.

Methods

This retrospective study included ICU patients with sepsis, identified according to the Sepsis-3 criteria, from the MIMIC-IV database (2008-2019). Eligible participants we

SUBMITTER: Yao F 

PROVIDER: S-EPMC12482257 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature