KDM4A-driven SMAD5/TGFβ axis activation as a therapeutic target in cholangiocarcinoma: mechanistic insights and translational implications.

ABSTRACT:

Background

Cholangiocarcinoma is a malignancy with poor prognosis and increasing incidence in recent years. Apart from early surgical resection, other treatments have shown limited efficacy. Lysine-specific demethylase 4A (KDM4A), a histone demethylase, is known to have a promotional effect on a variety of tumours. However, its impact on cholangiocarcinoma remains underexplored.

Methods

The expression differences of KDM4A in cholangiocarcinoma and adjacent tissues were analyzed by database and tissue microarray. The effects of KDM4A on the growth and proliferation ability of cholangiocarcinoma cells were explored through subcutaneous tumor formation experiments in nude mice and cholangiocarcinoma mouse models. The regulatory role of KDM4A on TGFβ pathway was analyzed by real

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12482258 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature