Dysregulated miR-1246 and miR-1253 link inflammatory protein markers in plasma to major depressive disorder in female adolescents.

ABSTRACT: Major depressive disorder (MDD) in adolescents is a prevalent psychiatric condition worldwide with severe consequences. Growing evidence shows that microRNAs (miRNAs) regulate many processes hypothesized to be involved in the pathogenesis of MDD including inflammation, suggesting their suitability as biomarkers. Still, more research is needed regarding miRNAs as biomarkers and the role of inflammation in adolescents with MDD. This study applied the NanoString nCounter technology to identify dysregulated miRNAs in plasma from hospitalized female adolescents with MDD compared to healthy controls, as well as before and after antidepressant treatment. A multiplexed immunoassay was also performed to assess the plasma levels of 27 inflammatory proteins. A total of 33 patients and 14 healthy cont

SUBMITTER: Johannessen K 

PROVIDER: S-EPMC12482293 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature