Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.

ABSTRACT: Astringency is a characteristic exhibited by only a limited number of polyphenolic compounds which show high electrochemical activity and are susceptible to oxidation at neutral pH conditions like the oral cavity and small intestine. Large-scale intervention studies have demonstrated that the astringent flavanol (FLs) can restore hippocampal-dependent memory. However, due to the low bioavailability of FLs, the mechanism of action remains unclear. In this study, we aimed to elucidate the mechanism by which FLs acts on the nervous system through the gastrointestinal tract. Following a single gavage dose of FLs to mice, spontaneous motor activity in the open field and improved short-term memory in the novel object test were enhanced. Concurrently, activation of stress response systems, such a

SUBMITTER: Fujii Y 

PROVIDER: S-EPMC12482304 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature