Hepatic Ketogenesis Regulates Lipid Homeostasis via ACSL1-mediated Fatty Acid Partitioning.

ABSTRACT:

Background & aims

Liver-derived ketone bodies play an essential role in energy homeostasis during fasting by supplying fuel to the brain and peripheral tissues. Ketogenesis also helps to remove excess acetyl-CoA generated from fatty acid oxidation, thereby protecting against diet-induced hepatic steatosis. Despite this, the role of ketogenesis in fasting-associated hepatocellular lipid metabolism has not been thoroughly investigated.

Methods

We used mice with liver-specific knockout of HMGCS2 mice to determine how ACSL1-mediated esterification contributes to fasting-induced steatosis and performed biochemical assays, gene expression profiling, Western blotting, and histologic analyses. We further investigated the association between HMGCS2 expression, lipid re-esterification

SUBMITTER: Mooli RGR 

PROVIDER: S-EPMC12482313 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature