Dimensional control of DNA nanostructures enhances cellular uptake and guides tissue-regenerative responses.

ABSTRACT: Precise regulation of cellular functions is fundamental for advancing tissue regeneration and drug delivery systems. Structural DNA nanotechnology enables the design of well-defined nanostructures, emerging as a promising platform in these biomedical applications. However, a clear understanding of how the dimensional properties of DNA nanostructures affect cellular uptake and biological responses remains limited. In this study, we constructed three distinct DNA nanostructures: a one-dimensional six-helix bundle (6HB), a two-dimensional three-point star, and a three-dimensional tetrahedron. We systematically evaluated their endocytic efficiency in five representative cell types: endothelial cells, dermal fibroblasts, myoblasts, chondrocytes, and osteoblasts. Among them, the 6HB exhibited th

SUBMITTER: Tang X 

PROVIDER: S-EPMC12482324 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature