Isoacteoside alleviates LPS-induced depressive-like behaviors in mice by inhibiting neuroinflammation through regulating microglial polarization and oxidative stress.

ABSTRACT: Recent studies have demonstrated a close association between neuroinflammation and depression. Isoacteoside (ISO) has recently been reported to exhibit anti-inflammatory properties. However, the effects of ISO on neuroinflammation-induced depression and its underlying mechanisms have not been fully elucidated. This study aimed to investigate the mechanism of ISO on neuroinflammation-induced depression from both in vivo and in vitro aspects. In the in vivo experiments, lipopolysaccharide (LPS) was used to induce depressive-like behavior in adult male C57BL/6J mice, which were subsequently detected using the open field test (OFT), forced swim test (FST), and tail suspension test (TST). Quantitative real-time polymerase chain reaction (qPCR) and western blot were employed to measure the expre

SUBMITTER: Bi J 

PROVIDER: S-EPMC12482327 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature