Impact of interaction between IL-21 gene variants and smoking status on susceptibility to rheumatoid arthritis.

ABSTRACT:

Background

In recent years, interleukin-21 (IL-21) has been found to be a key player in RA pathogenesis and progression, despite accumulating evidence on rheumatoid arthritis (RA) etiology, the precise contribution of IL-21 gene variants interacting with environmental exposures remains unexplored in population-based studies. Therefore, we performed this study to evaluate the impact of gene single nucleotide polymorphisms (SNPs) and their interaction with environment on RA risk.

Methods

In this study, Genomic DNA was extracted from whole blood samples (Invitrogen PureLink™ Genomic DNA Mini Kit), and targeted genotyping of four SNPs (rs2055979, rs12508721, rs2221903 and rs907715) of IL-21 gene was performed using polymerase chain reaction-restriction fragment length polymorphi

SUBMITTER: Lu X 

PROVIDER: S-EPMC12482331 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature