Psoriasis and phenotypic age acceleration in relation to all-cause and cardiovascular disease mortality risks in US adults.

ABSTRACT:

Background

Psoriasis is a chronic, immune-mediated inflammatory dermatosis associated with an elevated risk of cardiovascular disease (CVD) due to systemic inflammation and metabolic dysregulation. Phenotypic age acceleration (PhenoAge-accel) quantifies accelerated biological aging by comparing an individual's predicted 'phenotypic age' (based on immune/inflammatory markers and chronological age) to their actual age. Notably, both the onset and progression of psoriasis exhibit strong associations with biological aging process. The aim of this study was to investigate their combined effect on the risk of all-cause and CVD mortality.

Methods

This study included 11,443 participants from the National Health and Nutrition Examination Survey (NHANES) conducted during 2003-2006 and

SUBMITTER: Zhao WQ 

PROVIDER: S-EPMC12482366 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature