Advanced glycation end-product receptor gene (RAGE) polymorphisms in patients with acute coronary syndrome - a case-control study in the Polish population.

ABSTRACT:

Background

The development of coronary artery disease (CAD) is the result of complex interactions between environmental and genetic factors. While the former is well known, the genetic factors that predispose individuals to the development of CAD are still under investigation. The aim of our study was to investigate whether single nucleotide polymorphisms (SNPs) in the gene encoding the receptor for advanced glycation end products (RAGE), specifically rs2070600 G/A and rs184003 G/T, may determine predisposition to acute coronary syndrome (ACS) and severity of coronary artery disease (CAD) in the Polish population.

Methods

Two RAGE SNPs were genotyped in 336 patients with a history of acute coronary syndrome (ACS): 175 < 50 years, 161 ≥ 50 years, and 160 ethnically, age- and

SUBMITTER: Gutowska K 

PROVIDER: S-EPMC12482394 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature