Association between mean corpuscular hemoglobin concentration and mortality in ICU patients with acute kidney injury: a retrospective multicenter cohort study.

ABSTRACT:

Background

The prognostic value of mean corpuscular hemoglobin concentration (MCHC) in ICU patients with acute kidney injury (AKI) is unclear.

Methods

We performed a retrospective multicenter cohort study using MIMIC-IV and eICU-CRD. Adults with AKI and an admission MCHC (first 24 h) were included. Outcomes were 30-and 90-day in-hospital mortality. Survival was compared across MCHC quartiles, and Cox models (with restricted cubic splines) estimated adjusted associations.

Results

Among 111,817 patients (MIMIC-IV n = 54,422; eICU-CRD n = 57,395), higher MCHC was associated with lower mortality. Survival differed across MCHC quartiles (log-rank p < 0.0001 in both cohorts). In adjusted models, the highest vs. lowest MCHC quartile had a lower risk of death (MIMIC-IV HR 0.6

SUBMITTER: Chen S 

PROVIDER: S-EPMC12482438 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature