The MeaB bZIP transcription factor is needed for proper nitrosative stress response induced by nitrite in Aspergillus fumigatus.

ABSTRACT:

Background

MeaB is a bZIP-type transcription factor in fungi. This protein is known to regulate nitrogen metabolism, contribute to nitrite susceptibility and determine virulence in aspergilli. We hypothesized that MeaB is required for proper nitric oxide (NO) metabolism of fungi. Here, we tested this hypothesis on the human pathogenic fungus Aspergillus fumigatus using a transcriptomics approach.

Results

Deletion of the meaB gene increased nitrite, diethylamine NONOate and menadione-sodium bisulfite stress sensitivity, but not that of terc-butyl hydroperoxide or H₂O₂. The conidia of the ΔmeaB mutant showed no altered susceptibility to human macrophages. When the transcriptome of the ΔmeaB strain was compared with the wild-type strain (Af293), genes invo

SUBMITTER: Varga KE 

PROVIDER: S-EPMC12482460 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature