The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis.

ABSTRACT:

Background

Conditions like fibrosis, rheumatoid arthritis or cancer, once seen as distinct diseases, are now recognized to share strikingly common pathogenic mechanisms. The key to this convergence lies in the fibroblast, a pivotal driver of disease progression, tissue injury and chronicity. Despite this central pathogenic role and growing recognition as a therapeutic target, effective treatments targeting fibroblasts remain elusive, leaving a critical gap in disease intervention.

Methods

Here we present a novel approach to target fibrosis using the melanocortin compound BMS-470539 to treat in vitro cultured human dermal fibroblasts obtained from healthy volunteers and systemic sclerosis patients and measuring various markers of senescence and fibroblast activation combining

SUBMITTER: Davan-Wetton CS 

PROVIDER: S-EPMC12482462 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature