Superovulation alters telomere length and telomerase component levels in mouse oocytes.

ABSTRACT: Assisted reproductive technologies (ARTs) are widely used to treat infertility and include the fundamental step, controlled ovarian stimulation (also known as superovulation). Superovulation involves the administration of gonadotropins to produce a sufficient number of oocytes, either through single or repeated applications. However, superovulation can cause certain adverse effects such as increased oxidative stress, decreased oocyte quality, and mitochondrial dysfunction. As oxidative stress and mitochondrial dysfunction are closely associated with alterations in telomere length, we investigated the effects of single and repeated superovulation on expression of the telomerase components and telomere length in mouse oocytes at germinal vesicle (GV) or metaphase II (MII) stage. Additionally

SUBMITTER: Tire B 

PROVIDER: S-EPMC12482465 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature