Effects of topical ozonated olive oil on lipid profile, quality of life, wound healing and glycemic control in patients with diabetic foot ulcers: a randomized controlled trial.

ABSTRACT:

Introduction

Diabetic foot ulcers (DFUs) are a severe complication of diabetes, leading to infections, amputations, and reduced quality of life. Ozonated olive oil, combining ozone's antimicrobial properties with olive oil's biocompatibility, shows promise in chronic wound management. Limited evidence exists on its comprehensive effects in DFUs. This study evaluates its impact on wound healing, quality of life, glycemic control, lipid profiles, and inflammation.

Methods

A randomized controlled trial was conducted at a tertiary care center in Hormozgan Province (January-December 2024) with 123 adults (aged 18-75) with type-2 diabetes and Wagner grade 1-2 DFUs. Participants were randomized (1:1) to receive daily topical ozonated olive oil (50 g/m³, 5 mL) or standard care for 4

SUBMITTER: Vahedi S 

PROVIDER: S-EPMC12482489 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature