Obesity alters VLDL profile and remnant cholesterol differently in metabolically healthy men and women: a ¹H-NMR study.

ABSTRACT:

Background and aims

Lipoprotein particle (p) size and count beyond lipoprotein lipid content [triglycerides (tg) and cholesterol (c)] are critical for their atherogenicity. This study characterized lipoprotein profiles in metabolically healthy individuals with overweight or obesity and assessed the impact of sex, obesity, and lipid background.

Methods

Proton-nuclear magnetic resonance (¹H-NMR) was used to assess the composition of very low-, low-, intermediate-, and high-density lipoproteins (VLDL, LDL, IDL, HDL), and particle number and size of VLDL, LDL, and HDL in 101 healthy subjects with overweight and obesity.

Results

Men showed significantly higher VLDLc and VLDLtg levels, counts of VLDLp (all subfractions) and LDLp (total and small), and smaller LDLp size, com

SUBMITTER: Santisteban V 

PROVIDER: S-EPMC12482502 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature