Efficacy and safety of colchicine in patients with acute coronary syndrome: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

The European Society of Cardiology (ESC) recently endorsed low-dose colchicine for chronic coronary syndrome. However, its role in acute coronary syndrome (ACS) remains uncertain due to inconsistent trial outcomes. This systematic review and meta-analysis aimed to assess the efficacy and safety of colchicine in patients with ACS.

Methods

A comprehensive search of PubMed, Embase, and the Cochrane Library was conducted through April 2025 to identify randomized controlled trials (RCTs) evaluating colchicine in adults with ACS. The primary outcome was all-cause mortality. Secondary outcomes included cardiovascular mortality, stroke, myocardial infarction (MI), major adverse cardiovascular events (MACE), coronary revascularization, and gastrointestinal (GI) adverse eve

SUBMITTER: Fallahtafti P 

PROVIDER: S-EPMC12482528 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature