Lymphomatosis cerebri presenting with rapidly progressive parkinsonism and Holmes tremor: a case report.

ABSTRACT:

Background

Lymphomatosis cerebri (LC) is a rare subtype of primary central nervous system lymphoma (PCNSL) characterized by diffuse infiltration without mass formation. LC typically presents with cognitive decline and gait disturbances; however, extrapyramidal manifestations, including Parkinsonism and Holmes tremor, are exceedingly rare. This report describes a unique case highlighting the diagnostic challenges and atypical manifestations of LC.

Case presentation

A 75-year-old man presented with rapidly progressive cognitive decline, Parkinsonism, and Holmes tremor. Brain magnetic resonance imaging (MRI) revealed diffuse T2 and FLAIR hyperintensities involving the deep white matter, basal ganglia, and midbrain, without contrast enhancement. Despite normal dopamine transport

SUBMITTER: Iguchi T 

PROVIDER: S-EPMC12482555 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature