A LXG toxin stabilized by DUF4176 contributes to Streptococcus suis competition and pathogenicity.

ABSTRACT:

Background

Streptococcus suis poses a significant threat to both humans and pigs, causing severe disease such as meningitis, septicaemia, and sudden death. The type VII secretion system (T7SS) plays a crucial role in exporting effectors that mediate bacterial competition and colonization in polymicrobial environments. Although Leu-x-Gly (LXG) polymorphic toxins are among the main effectors secreted by the T7SS, the mechanism underlying their secretion remains to be fully elucidated.

Results

Here, we identified a complex repertoire of LXG effectors in S. suis, comprising at least five distinct LXG-domain groups and 14 C-terminal toxin types. We focused on one LXG effector, LXG1-CT3, from the virulent strain WUSS351, demonstrating its pore-forming activity and essential role i

SUBMITTER: Wu H 

PROVIDER: S-EPMC12482557 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature