Dataset Information
Intradiscal injection of allogeneic bone marrow derived clonal mesenchymal stromal cells in discogenic low back pain: a phase I study on safety and feasibility (RELIEF: phase I).
Ontology highlight
ABSTRACT: Aims
This is a phase I trial, assessing the feasibility, safety, and potential efficacy of intradiscal injection of allogeneic bone marrow-derived clonal mesenchymal stromal cells (BM-cMSCs) in patients suffering from discogenic low back pain (DLBP).Methods
Five patients underwent single intradiscal injection of 9 × 106 allogeneic BM-cMSCs and were followed at predefined intervals for 24 weeks. Safety outcomes included monitoring adverse events (AEs), serious adverse events (SAEs), and laboratory assessments. Efficacy endpoints were evaluated over 24 weeks and included Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and SF-36 quality-of-life scores. MRI was performed to assess disc height, apparent diffusion coefficient (ADC), and modified Pfirrmann grading.Results
No SAE was observed. Transient injection site pain was the most common AE which resolved within 4-8 days after injection. VAS decreased significantly in three patients, with pain relief sustained through 24 weeks. ODI indicated functional improvement in three patients, with two achieving minimal disability. SF-36 quality of life questionnaire outcomes demonstrated improvements in physical functioning and pain domains in three patients. MRI findings showed modest increases in disc height and apparent diffusion coefficient (ADC) improvements in 2 patients.Conclusions
Intradiscal injection of allogeneic BM-cMSCs appears to be safe and feasible as a potential therapy for DLBP, with promising efficacy in reducing pain and improving function and quality of life. Further studies with larger cohorts and extended follow-ups are needed to confirm these findings and explore long-term structural benefits.Trial registration
IRCT, IRCT20080728001031N30. Registered 21 October 2021, https://irct.behdasht.gov.ir/trial/58723 .
SUBMITTER: Maal AB
PROVIDER: S-EPMC12482575 | biostudies-literature | 2025 Sep
REPOSITORIES: biostudies-literature
Publications
Intradiscal injection of allogeneic bone marrow derived clonal mesenchymal stromal cells in discogenic low back pain: a phase I study on safety and feasibility (RELIEF: phase I).
Stem cell research & therapy 20250929 1
<h4>Aims</h4>This is a phase I trial, assessing the feasibility, safety, and potential efficacy of intradiscal injection of allogeneic bone marrow-derived clonal mesenchymal stromal cells (BM-cMSCs) in patients suffering from discogenic low back pain (DLBP).<h4>Methods</h4>Five patients underwent single intradiscal injection of 9 × 10<sup>6</sup> allogeneic BM-cMSCs and were followed at predefined intervals for 24 weeks. Safety outcomes included monitoring adverse events (AEs), serious adverse e ...[more]