The effect of longitudinal trajectories of triglyceride-glucose index on the incident metabolic dysfunction-associated steatotic liver disease.

ABSTRACT:

Background

The triglyceride-glucose (TyG) index is a reliable marker of insulin resistance and has been linked to metabolic disorders. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, particularly among older adults. The association between long-term changes in TyG levels and the risk of incident MASLD remains unclear. This study aimed to investigate the relationship between TyG index trajectories and the development of MASLD in the elderly.

Methods

We conducted a prospective cohort study involving 28,535 older adults who underwent annual health checkups from 2018 to 2021 with complete triglyceride and fasting blood glucose data. Group-based trajectory modeling was used to identify three distinct TyG trajectories: the

SUBMITTER: Wu X 

PROVIDER: S-EPMC12482581 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature