Biocide, antifungal susceptibility and virulence characteristics of Clade 1 Candidozyma auris strains.

ABSTRACT:

Background

Candidozyma auris is an emerging multidrug-resistant fungal pathogen responsible for nosocomial outbreaks worldwide. In addition to antifungal resistance, its ability to persist in the hospital environment and tolerate commonly used biocides presents a critical challenge for infection control. However, the relationship between biocide tolerance, antifungal resistance, and virulence traits in C. auris remains poorly understood.

Methods

In this study, 47 C. auris Clade 1 isolates were evaluated using phenotypic and genotypic methods. ITS region sequencing was performed using Oxford Nanopore technology. Susceptibility testing was conducted for seven antifungal agents and four biocides using the CLSI reference microdilution method. Virulence factors including biofilm

SUBMITTER: Kalkanci A 

PROVIDER: S-EPMC12482617 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature