The association of antiretroviral therapy type and duration of use with stroke in people living with HIV in Zambia.

ABSTRACT:

Background

People living with HIV (PLWH) are at increased risk of stroke due to many factors including possibly antiretroviral therapy (ART) use. We sought to evaluate the association between ART type and duration of use with stroke in PLWH.

Methods

We conducted a prospective exploratory case-control study at the University Teaching Hospital in Lusaka, Zambia between March 2022 and October 2024 in adult (≥ 18 years) PLWH comparing those with stroke (cases) and without (controls) matched (1:2) for age, sex and race. Standardized data collection instruments were used to collect clinical, laboratory and imaging information. This information was compared between the cases and controls using Chi-square, t-tests, Mann-Whitney U-test (not normally distributed) and multivariable con

SUBMITTER: Zimba S 

PROVIDER: S-EPMC12482629 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature