Coenzyme-based elastomeric adhesive patch as iron ion capturer to regulate iron metabolism for diabetic oral ulcer repair.

ABSTRACT: Iron metabolism imbalance under high-glucose and nutrient-rich conditions is a key factor inhibiting the healing of diabetic oral ulcers. This study confirms the extensive iron accumulation and ferroptosis occurrence in diabetic oral ulcers. To address this, an oral patch (PLTP) is designed by combining two natural bioactive molecules of lipoic acid (LA) and tea polyphenols (TP). The abundant carboxyl and hydroxyl groups in PLTP act as iron ion capturers, adsorbing extracellular iron, reducing iron transport into cells, and effectively cutting off the iron source for intracellular ferroptosis. The in-situ release of LA and TP at wound site not only aids in restoring intercellular iron homeostasis via regulating the intracellular Xc^-/GPX4 axis, enhancing antioxidant capacity, upr

SUBMITTER: Yang R 

PROVIDER: S-EPMC12482644 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature