LAG-3 palmitoylation-inducing dysfunction of decidual CD4⁺T cells is associated with recurrent pregnancy loss.

ABSTRACT: Recurrent pregnancy loss (RPL) profoundly impacts not only the physical health but also the psychological well-being of women. Despite its profound effects, the underlying pathophysiological mechanisms of RPL remain largely elusive, with few discernible warning signs. Lymphocyte activation gene-3 (LAG-3) is a crucial immune checkpoint that modulates immune responses during infection and tumor. In the present study, we examined the expression of LAG-3 on CD4⁺T cells during pregnancy via cytometry by time-of-flight and flow cytometry. Our findings revealed a higher frequency of LAG-3⁺ decidual CD4⁺T (dCD4⁺T) cells in response to trophoblasts during normal pregnancy. This specific LAG-3⁺ subset of dCD4⁺T cells was found to prod

SUBMITTER: Cui L 

PROVIDER: S-EPMC12482660 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature