Evaluation of antibacterial and antibiofilm efficacy of gentamicin-loaded solid lipid nanoparticles (GM-SLNs) against Acinetobacter baumannii infections.

ABSTRACT: Acinetobacter baumannii has become a notable "superbug" due to its rapid development of resistance to multiple classes of antibiotics. This study aimed to evaluate the antibacterial and antibiofilm effectiveness of gentamicin-loaded solid lipid nanoparticles (GM-SLNs) in treating infections caused by A. baumannii. Nanoparticles were synthesized using the double melt emulsion dispersion method. A. baumannii was isolated from wounds, blood, urine, and sputum through standard microbiological techniques. Antimicrobial susceptibility was tested using the Kirby-Bauer disk diffusion method. The biofilm-forming ability of A. baumannii isolates, the antibacterial activity of GM-SLNs, and the time killing assay were conducted following standard protocols with slight modifications. The impact of GM-S

SUBMITTER: Nazari M 

PROVIDER: S-EPMC12482661 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature