Shenling Baizhu San attenuates testicular spermatogenic dysfunction in hyperuricemic mice via dual modulation of MAPK/NF-κB and NLRP3 inflammasome pathways.

ABSTRACT:

Context

Hyperuricemia (HUA) is a known factor contributing to testicular spermatogenic dysfunction. Shenling Baizhu San (SLBZS), a traditional Chinese medicine compound, has demonstrated efficacy in reducing uric acid levels. However, its specific impact on testicular spermatogenic function in mice with HUA remains unclear.

Objective

To investigate the impact and mechanism of SLBZS on testicular spermatogenic function in HUA mice.

Materials and methods

A hyperuricemia-induced spermatogenic dysfunction model was created by administering intraperitoneal injections of potassium oxonate (600 mg/kg/d) for seven days. Following model establishment, 48 Balb/c mice were randomly divided into six groups: control, model, low-dose SLBZS (5.04 g/kg/d), medium-dose SLBZS (10.07 g/

SUBMITTER: Jiang X 

PROVIDER: S-EPMC12482675 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature