Helicobacter pylori infection is associated with an increased risk of chronic obstructive pulmonary disease and asthma.

ABSTRACT:

Background

Helicobacter pylori infection, commonly observed in peptic ulcers, induces chronic systemic inflammation. Chronic obstructive pulmonary disease (COPD) and asthma are inflammatory airway diseases. We investigated the association of H. pylori infection with COPD and asthma.

Methods

Data from individuals who underwent H. pylori eradication treatment between 2009 and 2017 were obtained from the Korean National Health Insurance Database. In total, 33,017 individuals aged ≥ 40 years with H. pylori infection and 168,524 matched controls were identified and monitored until December 2019. Multivariate Cox proportional hazards models were used to estimate the adjusted hazard ratios (aHR) for risk factors associated with COPD and asthma.

Results

The incidences of COPD

SUBMITTER: Chung C 

PROVIDER: S-EPMC12482689 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature