Brain structural alterations correlate with motor dysfunction in children with spastic cerebral palsy: a quantitative MRI study.

ABSTRACT:

Background

Spastic cerebral palsy (CP) is a common cause of motor disability in children which caused by non-progressive brain injury. This study aimed to investigate the correlation between quantitative brain MRI parameters and motor dysfunction in children with spastic CP.

Methods

91 children with spastic CP and 91 controls were recruited. Brain volumes were measured using high-resolution T1-weighted Magnetic resonance imaging (MRI). Gross motor function was assessed using Gross Motor Function Measure-66 score (GMFM-66) and the muscle tone was evaluated by modified Ashworth scale and scored by modified Ashworth scale score.

Results

Children with spastic CP showed significantly reduced total brain volume, white matter volume, gray matter volume, and white matter/tota

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12482735 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature