External validation and comparison of clinical prediction models for cisplatin-associated acute kidney injury: a single-centre retrospective study.

ABSTRACT:

Background

Cisplatin-associated acute kidney injury (C-AKI) is a major complication of cisplatin therapy. Although two clinical prediction models have been developed for the US population, their external validity in the Japanese population remains unclear. This study aimed to evaluate the external validity of these models and compare their predictive performances in a Japanese cohort.

Methods

We assessed the performance of two C-AKI prediction models developed by Motwani et al. and Gupta et al. in a retrospective cohort of 1,684 patients treated with cisplatin at Iwate Medical University Hospital. C-AKI was defined as a ≥ 0.3 mg/dL increase in serum creatinine or a ≥ 1.5-fold rise from baseline. Severe C-AKI was defined as a ≥ 2.0-fold increase or renal replacement therapy i

SUBMITTER: Saito K 

PROVIDER: S-EPMC12482746 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature