N6-methyladenosine improves porcine longissimus dorsi muscle quality by regulating myofiber differentiation.

ABSTRACT:

Background

The pivotal roles of post-transcriptional N6-methyladenosine (m⁶A) modification in animal muscle development regulation have been wildly reported previously. However, whether this epigenetic mechanism also takes part in the muscle fiber differentiation, which remarkedly affects the meat quality and production in livestock, remains unknown.

Results

In this study, an eight-breeds crossbreed mosaic pig population consisted by 302 adult pigs was constructed to estimate the myofiber phenotypes. We found that despite the same genetic background, remarkable differences of longissimus dorsi muscle fiber types still existed between different subsets of this population. m⁶A abundance was evaluated subsequently in the subset samples with extremely low (

SUBMITTER: Yin C 

PROVIDER: S-EPMC12482748 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature